Cornelius K. Donat, Maria Yanez Lopez, Magdalena Sastre, Nicoleta Baxan, Marc Goldfinger, Reneira Seeamber, Franziska Müller, Polly Davies, Peter J. Hellyer, Petros Siegkas, Steve Gentleman, David Sharp, Mazdak Ghajari
Brain, 2020
Brain modelling · Past project
From biomechanics to pathology
Linking head loading to structural changes in white matter weeks after injury.
Combining high-fidelity biomechanics modelling, controlled cortical impact in rats, high-intensity MRI, and quantitative histopathology, we showed that brain deformations at the time of injury predict structural white-matter changes two weeks later, confirming the validity of using deformation to predict short and long-term outcomes.
The link between mechanical loading of brain tissue and the damage that follows weeks later is hard to demonstrate cleanly.
We combined brain computational modelling with controlled cortical impacts in rats, high-intensity MRI, and quantitative histopathology to test whether brain deformation at the time of injury predicts later structural changes.
We found that brain deformations at the time of injury predicts structural changes in white matter and astroglial activation two weeks post-injury, confirming brain strain and strain rate are valid predictors of brain injury after mechanical loading.
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Siamak Farajzadeh Khosroshahi, Xianzhen Yin, Cornelius K. Donat, Aisling McGarry, Maria Yanez Lopez, Nicoleta Baxan, David Sharp, Magdalena Sastre, Mazdak Ghajari
Scientific Reports, 2021