Traumatic brain injury (TBI) and mortality in older adults with and without pre-injury dementia

Helen Lai, Eyal Soreq, Niall Bourke, Claire Baker, Karl Zimmerman, Megan E Parkinson, Sarah Daniels, Edward W. Gregg, David Sharp, Lucia M. Li

medRxiv, 2024

Abstract

Importance Incidence of traumatic brain injury (TBI) is rising in older adults. Dementia is a common comorbidity amongst older adults and may worsen post-TBI outcomes, but this has not been systematically studied. Objective To compare all-cause mortality following TBI or non-TBI trauma (NTT), and quantify the impacts of age, deprivation, and pre-injury dementia. Design Population-based retrospective cohort study Setting Electronic health records (EHRs) from primary and secondary care Participants Adult residents in Wales aged 18-100 with TBI or NTT from January 2000 to December 2022 Exposures Traumatic (intracranial) brain injury (TBI) or non-TBI trauma (NTT) recorded in secondary care. Pre-injury diagnosis of dementia within primary or secondary care. Main Outcomes and Measures All-cause mortality within 1, 6, and 12 months of hospitalised TBI/NTT in those with and without pre-injury dementia. Cox proportional hazard models were used to estimate survival probability across groups. Groups were propensity-matched by age, sex, and health conditions. Models were stratified by sex, age, and deprivation. Results 23,428 TBIs (n=18,940) and 589,169 NTTs (n=421,259) were identified. TBIs…

Cite as (BibTeX)

@article{lai-2024-traumatic-brain-injury-tbi,
  title={Traumatic brain injury (TBI) and mortality in older adults with and without pre-injury dementia},
  author={Helen Lai and Eyal Soreq and Niall Bourke and Claire Baker and Karl Zimmerman and Megan E Parkinson and Sarah Daniels and Edward W. Gregg and David Sharp and Lucia M. Li},
  journal={medRxiv},
  year={2024},
  doi={10.1101/2024.10.09.24314691}
}